Lee Ann Baxter-Lowe, Ph.D., dip.ABHI
Professor in Residence
Division of Transplant Surgery
Director, Immunogenetics and TransplantationLaboratory
Contact Information
BiographyEducation
- 1968-72, University of Wisconsin, Madison, B.S., Biochemistry
- 1972-76, University of Wisconsin, Madison, Ph.D., Biochemistry
Postdoctoral Training
- 1977-82, University of Wisconsin, Madison, Postdoctoral Fellow, Biochemistry
Board Certification
- Laboratory Director for Histocompatibility and Engraftment Monitoring, New York
- Board Certification, American Board of Histocompatibility and Immunogenetics
- Histocompatibility Laboratory Director, California
Research Interests
- HLA polymorphism
- Molecular basis for allorecognition
- Risk factors for formation of HLA antibodies after a sensitizing event
- Role of KIR in transplantation
- Role of microchimerism in disease
- Role of microchimerism in transplantation
Biography
Lee Ann Baxter-Lowe, PhD, dip.ABHI is the Director of the UCSF Immunogenetics and Transplantation Laboratory and a Professor in Residence in the UCSF Medical School Department of Surgery. Dr. Baxter-Lower has more than 20 years experience in histocompatibility testing and transplantation research. Her research in characterization of HLA polymorphism and investigation of the relationship between HLA matching and transplant outcomes has been translated into state-of-the-art services in the Immunogenetics and Transplantation Laboratory. Her research involving mixed chimerism and microchimerism has provided the basis for sensitive tests that are now available as a clinical service.
Dr. Baxter-Lowe has led the Immunogenetics and Transplantation Laboratory since 1998. Under her guidance, the ITL has developed into a world leader in the most sophisticated HLA typing methods. The laboratory has expanded its test menu, introduced new technology including bead arrays, dramatically increased clinical consultation, revamped the quality systems program, and attracted referrals from other academic institutions.
Dr. Baxter-Lowe's other accomplishments include more than 100 peer-reviewed scientific publications, the first report describing use of high resolution molecular HLA typing for the selection of an unrelated bone marrow donor, patents for methods for molecular HLA typing and characterization of HLA polymorphism, including discovery of many HLA alleles. She has served in leadership positions for the development of national standards for histocompatibility testing rincipal investigator or co-investigator for numerous basic and translational research projects.
Selected Publications
- Flomenberg, N, LA Baxter-Lowe, D Confer, M Fernandez-Vina, A Filipovich, M Horowitz, C Hurley, C Kollman, C Anasetti, H Noreen, A Begovich, W Hildebrand, E Petersdorf, B Schmeckpeper, M Setterholm, E Trachtenberg, T Williams, E Yunis, and D Weisdorf (2004) Impact of HLA Class I and Class II High Resolution Matching on Outcomes of Unrelated Donor Bone Marrow Transplantation: HLA-C Mismatching Is Associated with a Strong Adverse Effect on Transplant Outcome. Blood 104(7): 1923-30.
- Bernardin F, D Kong, L Peddada, LA Baxter-Lowe, and E Delwart (2005). Human Immunodeficiency Virus Mutations during the First Month of Infection Are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes. Journal of Virology 79(17): 11523-8.
- Kurtzberg J, MCairo, LA Baxter-Lowe, S Carter, G Cohen, J Fraser and N Kernan (2005) Results of the Cord Blood Transplantation Study (COBLT) Unrelated Donor Program. Transfusion 45:842-55.
- Steere A, W Klitz, E Drouin, B Falk, W Kwok, G Nepom, LA Baxter-Lowe (2006) Antibiotic-Refractory Lyme Arthritis and HLA-DR Molecules that Bind the OspA163-175 Epitope of Borrelia burgdorferi. Journal of Experimental Medicine 203(4): 961-71.
- Horn B, LA Baxter-Lowe, L Englert, A McMillan, M Quinn, K Desantes, M Cowan. (2006) Reduced Intensity Conditioning using Intravenous Busulfan, Fludarabine and Rabbit ATG for Children with Nonmalignant Disorders and CML. Bone Marrow Transplant. 37(3):263-9.
